Neuroimmune System Plays Major Role In Weight Regulation

In the brain, the cells associated with the immune system may cause weight gain. We can notice this in mice. Some immune cells in their brain can make a fatty diet more fattening. Microglia in Hypothalamus may use in obesity treatments. More dietary stimulates the gathering of microglia in MBH(mediobasal hypothalamus. An inflammatory signal of microglia determines an immunologic response of hypothalamus and regulates the homeostasis in mice.


The signal of NF-κB reduced microgliosis and it prevents the entry of MBH by myeloid cells which are derived from bone marrow. Thus it increases the hyperphagia and weight gain.



After deletion of the negative NF-κB regulator, A20 Microglia becomes active.
And it promotes impetus in MBH microgliosis with cellular infiltration and increased both food intake and weight gain. Thus more dietary stimulate activate microglial inflammatory and provide non-neuronal approaches to tret metabolic diseases.



There are few Drugs which may help to treat Obesity For example PLX3977. It made by Plexxikon, and now is in clinical trials to treat tumors, leukemias and rare form of arthritis. It follows the same mechanism action as PLX522. During this experiment, the UCSF team used to reduce microglia numbers that could be helpful to make a survey on cancer patients with respect to their body weights beneficial effect by using PLX3977 in clinical trials.


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